KLOW 80mg- /Ghk-Cu 50mg/ BPC-157 10mg/ KPV 10mg/ TB500 10mg
KLOW Peptide Blend (RUO) | High Purity ≥99% | Research Grade
Product Specifications
| Specification | Details |
|---|---|
| Product Name | KLOW Multi-Peptide Research Blend |
| Total Content | 80mg (GHK-Cu 50mg + BPC-157 10mg + TB-500 10mg + KPV 10mg) |
| GHK-Cu CAS | 89030-95-5 |
| BPC-157 CAS | 137525-51-0 |
| TB-500 CAS | 77591-33-4 |
| KPV CAS | 69630-60-0 |
| Purity | ≥99% (RP-HPLC Verified Per Component) |
| Identity Confirmation | LC-MS Verified — All Four Components Per Batch |
| Form | Co-Lyophilized Powder |
| Solubility | Bacteriostatic Water or Sterile PBS |
| Storage | 2–8°C lyophilized; −20°C reconstituted. Protected from light and moisture. |
What Is KLOW?
KLOW is a precision co-lyophilized four-component peptide research blend supplied exclusively for laboratory and preclinical research applications. Each component targets a distinct biological pathway — extracellular matrix remodeling, angiogenic signaling, cytoskeletal dynamics, and inflammatory pathway modulation — making KLOW a uniquely comprehensive tool for researchers investigating multi-pathway regenerative biology within a single controlled experimental system.
The four components and their characterized mechanistic roles are as follows. GHK-Cu (Copper Tripeptide-1, 50mg) is a naturally occurring copper-complexed tripeptide studied for ECM remodeling, collagen synthesis, and antioxidant pathway modulation. BPC-157 (10mg) is a synthetic pentadecapeptide characterized for VEGFR2/Akt-eNOS angiogenic signaling and nitric oxide pathway activation. TB-500 (Ac-LKKTETQ, 10mg) is a thymosin beta-4 fragment studied for its LKKTET actin-binding domain, G-actin sequestration, and cytoskeletal organization in cell migration models. KPV (Lys-Pro-Val, 10mg) is the C-terminal tripeptide fragment of alpha-MSH, characterized for competitive inhibition of NF-κB nuclear translocation via importin-α3 binding at nanomolar concentrations — the mechanistic pathway that distinguishes KLOW from the three-component GLOW blend.
The fixed 50mg:10mg:10mg:10mg ratio is produced in a single co-lyophilization run, ensuring uniform molar composition across every aliquot prepared from a single batch and eliminating inter-batch variance associated with manual multi-peptide preparation.
This product is clearly labeled and distributed strictly as a Research Use Only (RUO) material and is not approved for human or veterinary use.
Experimental Research Applications
In scientific literature, the four KLOW components have been investigated individually and in combination in a variety of experimental settings, including:
- ECM remodeling and collagen synthesis research (GHK-Cu)
- Angiogenesis and VEGFR2/Akt-eNOS vascular signaling studies (BPC-157)
- Actin polymerization, cytoskeletal organization, and cell migration assays (TB-500)
- NF-κB nuclear translocation inhibition and inflammatory pathway modulation (KPV)
- MAPK signaling suppression and cytokine secretion studies
- Fibroblast viability, motility, and scratch-wound closure assay research
- Multi-pathway regenerative biology and ECM interaction studies
- Comparative single-component vs. multi-component pathway research
These studies are conducted exclusively within laboratory and preclinical environments and are intended for mechanistic and observational research purposes.
Purity and Quality Control
Each batch of KLOW undergoes analytical testing to ensure:
✔ ≥99% purity verified by RP-HPLC per component
✔ LC-MS identity and molecular weight confirmation for all four components per batch
✔ Fixed 50:10:10:10 ratio confirmed at manufacture
✔ Batch-to-batch consistency
✔ Professional documentation and traceability
✔ Controlled manufacturing standards
✔ Reliable performance for repeatable research applications
High analytical purity and strict quality control procedures help provide researchers with confidence in the consistency and reliability of each batch.
Key Research Features
- Four-component co-lyophilized research blend — four simultaneous mechanistic pathways
- GHK-Cu: ECM remodeling, collagen synthesis, copper coordination chemistry
- BPC-157: VEGFR2/Akt-eNOS angiogenic signaling, NO pathway modulation
- TB-500: actin sequestration, cytoskeletal dynamics, cell migration
- KPV: NF-κB nuclear translocation inhibition via importin-α3 competitive binding
- Fixed 50:10:10:10mg ratio — single co-lyophilization run ensures uniform aliquot composition
- ≥99% RP-HPLC-verified purity per component
- Lyophilized powder format
- Suitable for in vitro and preclinical research
- Batch-tested for consistency
- Research-grade manufacturing standards
- Professionally labeled and documented
Storage Recommendations
To maintain product stability and research integrity, KLOW should be:
- Stored at 2–8°C (lyophilized) or −20°C (reconstituted)
- Reconstituted in bacteriostatic water or sterile PBS, added slowly with gentle swirling — do not vortex
- Aliquoted immediately into single-use working volumes after reconstitution
- Protected from light and moisture
- Kept sealed until use
- Handled according to standard laboratory procedures
- Not subjected to repeated freeze-thaw cycles
Toxicology and Regulatory Information
- All four components evaluated in preclinical toxicology and regenerative biology research models
- All four components designated FDA Category 2 bulk substances (503A/503B compounding lists, September 2023)
- Compounding by licensed 503A/503B pharmacies for human use prohibited for all four components
- Not evaluated by the FDA for safety or efficacy in any therapeutic application
- Supplied strictly as a Research Use Only (RUO) material
- PPE required: gloves, lab coat, protective eyewear; refer to SDS for CAS 89030-95-5, 137525-51-0, 77591-33-4, and 69630-60-0
Why Choose Summit Pep Labs?
At Summit Pep Labs, we are committed to supplying researchers with premium-quality compounds manufactured to rigorous analytical standards.
Why Researchers Choose Summit Pep Labs
- ≥99% RP-HPLC-verified purity per component
- LC-MS identity confirmed for all four components — not purity alone
- Fixed ratio co-lyophilization — uniform aliquot composition across all replicates
- Endotoxin screened per batch (<0.25 EU)
- Batch consistency and traceability
- Professional labeling and packaging
- Research-grade manufacturing standards
- Secure cold-chain shipping and quality assurance
- Commitment to reproducibility and reliability
Frequently Asked Questions
What is KLOW?
KLOW is a co-lyophilized four-component peptide research blend combining GHK-Cu, BPC-157, TB-500, and KPV in a fixed ratio, commonly referenced in laboratory research for simultaneous investigation of ECM remodeling, angiogenic signaling, cytoskeletal dynamics, and NF-κB inflammatory pathway modulation.
What does the 80mg total content mean?
The 80mg refers to total lyophilized peptide content across all four components: GHK-Cu (50mg) + BPC-157 (10mg) + TB-500 (10mg) + KPV (10mg). The ratio is fixed at manufacture in a single co-lyophilization run, ensuring uniform molar composition across all reconstituted aliquots from a single batch.
What makes KLOW different from the GLOW blend?
KLOW contains KPV (Lys-Pro-Val), a tripeptide not present in GLOW. KPV directly inhibits NF-κB nuclear translocation via competitive importin-α3 binding, suppressing pro-inflammatory cytokine secretion at nanomolar concentrations in cell-based models. This adds a fourth mechanistic pathway — inflammatory signaling modulation — that the three-component GLOW blend does not address.
Why is GHK-Cu dosed at 50mg while the other components are 10mg each?
GHK-Cu is a copper-metal complex requiring sufficient peptide concentration to ensure complete Cu²⁺ coordination chemistry in aqueous reconstitution. The 50:10:10:10 ratio ensures effective metal-ligand complexation across the reconstituted volume and reflects the compositional standard documented in published KLOW formulation literature.
Is KLOW approved for human use?
No. All four KLOW components are FDA Category 2 bulk substances with no approved therapeutic indication. This blend is not approved for human or veterinary use and is supplied exclusively for research purposes.
What purity does Summit Pep Labs provide?
Each batch is tested and verified to contain ≥99% purity per component by RP-HPLC, with LC-MS identity confirmation for all four peptides and endotoxin screening per batch.
How is KLOW supplied?
KLOW is supplied as a co-lyophilized powder in a hermetically sealed sterile container and packaged according to professional research standards.
How should KLOW be stored and reconstituted?
Store lyophilized material at 2–8°C, protected from light and moisture. Reconstitute in bacteriostatic water or sterile PBS, adding solvent slowly with a gentle swirling motion — do not vortex. Aliquot immediately into single-use working volumes and store at −20°C. Avoid repeated freeze-thaw cycles.
References
- Sung J et al. Tissue and Cell. 2025;95:102837 — KPV MAPK/NF-κB suppression
- Viennois E et al. Gastroenterology. 2008;134:162. PMID: 18061177 — KPV PepT1/NF-κB mechanism
- Walters MJ et al. Orthopaedic J Sports Med. 2025 (PMC12313605) — BPC-157 systematic review
- Pickart L et al. BioImpacts. 2024. PMID: 39963574 — GHK-Cu ECM review
- Xing Y et al. Front Endocrinol. 2021;12:767785 — TB-500 thymosin beta-4 function
- Pickart L, Margolina A. Int J Mol Sci. 2018 (PMC6073405) — GHK-Cu gene modulation
- FDA Compounding Category 2 Bulk Substances List. September 2023
- National Center for Biotechnology Information (NCBI)
- U.S. Food and Drug Administration (FDA)
Research Use Only Disclaimer
For Research Use Only (RUO).
This product is intended strictly for laboratory and scientific research purposes. It is not intended for human consumption, veterinary use, cosmetic applications, therapeutic use, or diagnostic purposes.
By purchasing this product, customers acknowledge that they are qualified researchers and agree to use these materials in accordance with all applicable laws and regulations.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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