KPV 10mg

 

KPV 10mg

KPV – Research Grade Peptide

KPV (RUO) | High Purity ≥99% | Research Grade

Product Specifications

What Is KPV?

KPV is a synthetic tripeptide consisting of the amino acids lysine, proline, and valine (Lys-Pro-Val). It corresponds to the C-terminal fragment (positions 11–13) of alpha-melanocyte-stimulating hormone (α-MSH), a 13-amino-acid neuropeptide derived from proopiomelanocortin (POMC).

Despite its small size, KPV retains significant anti-inflammatory activity associated with the parent α-MSH molecule while lacking the melanocortin receptor binding sequence responsible for pigmentary effects. Research has shown that KPV can enter cells (including via the PepT1 transporter) and inhibit NF-κB signaling, a central pathway involved in the transcription of pro-inflammatory cytokines.

Identified by CAS Number 67727-97-3, KPV is commonly utilized in laboratory and preclinical research focused on inflammatory signaling, intestinal barrier models, and immune modulation studies.

This product is clearly labeled and distributed strictly as a Research Use Only (RUO) material and is not approved for human or veterinary use.

Experimental Research Applications

In scientific literature, KPV has been investigated in a variety of experimental settings, including:

• Anti-inflammatory pathway research and NF-κB inhibition studies
• Intestinal inflammation and colitis models (e.g., DSS- and TNBS-induced)
• Cellular uptake via the PepT1 (SLC15A1) peptide transporter
• Pro-inflammatory cytokine modulation (TNF-α, IL-6, IL-1β, IL-8)
• Gut barrier integrity and epithelial inflammation research
• Skin and keratinocyte inflammatory response models
• Comparative studies of α-MSH fragments and melanocortin-derived peptides
• Antimicrobial and immunomodulatory activity investigations

These studies are conducted exclusively within laboratory and preclinical environments and are intended for mechanistic and observational research purposes.

Purity and Quality Control

Each batch of KPV undergoes analytical testing to ensure:

✔ ≥99% purity verified by HPLC ✔ Identity confirmation by HPLC / LC-MS per batch ✔ Batch-to-batch consistency ✔ Professional documentation and traceability ✔ Controlled manufacturing standards ✔ Reliable performance for repeatable research applications

High analytical purity and strict quality control procedures help provide researchers with confidence in the consistency and reliability of each batch.

Key Research Features

• C-terminal tripeptide fragment of α-MSH (Lys-Pro-Val)
• Anti-inflammatory activity independent of melanocortin receptor pigmentation pathways
• Studied for NF-κB pathway inhibition
• Small molecular size with PepT1 transport potential
• ≥99% HPLC-verified purity
• Lyophilized powder format
• Suitable for in vitro and preclinical research
• Batch-tested for consistency
• Research-grade manufacturing standards
• Professionally labeled and documented

Storage Recommendations

To maintain product stability and research integrity, KPV should be:

• Stored at −20°C in a tightly sealed container
• Protected from light and moisture
• Reconstituted in sterile or bacteriostatic water
• Kept sealed until use
• Handled according to standard laboratory procedures
• Not subjected to repeated freeze-thaw cycles

Toxicology and Regulatory Information

• Not FDA-approved for any therapeutic indication
• Supplied strictly as a Research Use Only (RUO) material
• Intended exclusively for laboratory research by qualified professionals

Why Choose Summit Pep Labs?

At Summit Pep Labs, we are committed to supplying researchers with premium-quality compounds manufactured to rigorous analytical standards.

Why Researchers Choose Summit Pep Labs

• ≥99% HPLC-verified purity
• Batch-specific identity confirmation
• Batch consistency and traceability
• Professional labeling and packaging
• Research-grade manufacturing standards
• Secure cold-chain shipping and quality assurance
• Commitment to reproducibility and reliability

Frequently Asked Questions

What is KPV? KPV is a tripeptide with the sequence Lys-Pro-Val. It is the C-terminal fragment (positions 11–13) of alpha-melanocyte-stimulating hormone (α-MSH) and is studied primarily for its anti-inflammatory properties in laboratory research.

How does KPV differ from full-length α-MSH? Full-length α-MSH has both anti-inflammatory and pigmentary (melanogenic) effects. KPV retains anti-inflammatory activity while lacking the core melanocortin receptor sequence responsible for skin pigmentation effects.

What research areas is KPV commonly studied in? KPV has been investigated in models of intestinal inflammation, NF-κB signaling inhibition, cytokine modulation, gut barrier function, and skin inflammatory responses.

Is KPV approved for human use? No. KPV is supplied exclusively as a Research Use Only (RUO) material and is not approved for human consumption, therapeutic use, or any clinical application.

What purity does Summit Pep Labs provide? Each batch of KPV is tested and verified to contain ≥99% purity using HPLC analytical methods, with identity confirmation performed per batch.

How is KPV supplied? KPV is supplied as a lyophilized powder packaged according to professional research standards.

How should KPV be stored? Store at −20°C, protected from light and moisture. Reconstitute with sterile or bacteriostatic water. Avoid repeated freeze-thaw cycles.

References

• Dalmasso G et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008
• Luger TA et al. α-Melanocyte-stimulating hormone and related tripeptides. Ann N Y Acad Sci.
• PubChem Compound Summary — KPV / Lys-Pro-Val
• National Center for Biotechnology Information (NCBI)
• U.S. Food and Drug Administration (FDA) — Research Use Only Framework

Research Use Only Disclaimer

For Research Use Only (RUO).

This product is intended strictly for laboratory and scientific research purposes. It is not intended for human consumption, veterinary use, cosmetic applications, therapeutic use, or diagnostic purposes.

By purchasing this product, customers acknowledge that they are qualified researchers and agree to use these materials in accordance with all applicable laws and regulations.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.